Personnel > Research center

Izpisúa Belmonte, Juan Carlos

Izpisúa Belmonte, Juan Carlos

Our Director

izpisua@cmrb.eu


Juan Carlos Izpisúa Belmonte studies how genes and molecules orchestrate the development of an embryo. The questions addressed by the laboratory include: How does one cell give rise to millions of cells, and how do they come to be organized into complete structures such as limbs, a heart or brain? How stems cells differentiate and give rise to over 200 cell types that constitute the human body? How certain animals are able to regenerate their tissues and organs, i.e., what are the genetic pathways responsible for epimorphic regeneration, a complex biological process by which animals can regenerate tissues and even entire organs throughout their lifetime after injury or amputation?

Izpisua Belmonte Lab

The Izpisúa Belmonte laboratory utilizes different in vivo (mouse, chick, frog, and axolotl) and in vitro (human and mouse stem cells) model systems, as well as in silico modeling approaches, with particular emphasis on the genetic pathways involved in heart and bone development and regeneration. Their research has helped to discover some of the molecules that instruct embryonic stem cells to give rise to specific cell types during embryo development, and how these cells interact with one another to form tissues and organs with proper morphology and function. This ensures that our body's organs develop and function correctly and, at the same time, are placed in their correct positions.



The research activities of Dr. Izpisúa Belmonte's laboratory are relevant to understanding the causes that underlie human birth defects, as well as to the future development of regenerative medicine

Selected Publications

  • Nivet E, Liu GH, Montserrat N, Izpisua Belmonte JC. (2013) [Resetting Parkinson's disease patient-derived cells to unveil new pathological marks]. Reprogrammer les cellules de patients parkinsoniens pour révéler de nouvelles marques pathologiques de la maladie. Med Sci (Paris) 29(4):353-5.
  • Barrero MJ, Sese B, Martí M, Izpisua Belmonte JC. (2013) Macro histone variants are critical for the differentiation of human pluripotent cells. J Biol Chem Apr 17. [Epub ahead of print]
  • Masuda S, Izpisua Belmonte JC. (2013) At the crossroads of targeted treatment and resistance in melanoma. Lancet Oncol 14(4):e136-7.
  • Barrero MJ, Izpisua Belmonte JC. (2013) Polycomb complex recruitment in pluripotent stem cells. Nat Cell Biol 15(4): 348-50.
  • Barrero MJ, Sese B, Kuebler B, Bilic J, Boue S, Martí M, Izpisua Belmonte JC. (2013) Macrohistone Variants Preserve Cell Identity by Preventing the Gain of H3K4me2 during Reprogramming to Pluripotency. Cell Rep Mar 27. [Epub ahead of print].
  • Sander V, Suñe G, Jopling C, Morera C, Izpisua Belmonte JC. (2013) Isolation and in vitro culture of primary cardiomyocytes from adult zebrafish hearts. Nat Protoc 8(4): 800-9.
  • Peran M, Ruiz S, Kwiatkowski W, Marchal JA, Yang SL, Aranega A, Choe S, Izpisua Belmonte JC. (2013) Activin/BMP2 chimeric ligands direct adipose-derived stem cells to chondrogenic differentiation. Stem Cell Res 10(3):464-476.
  • Pan H, Cai N, Li M, Liu GH, Izpisua Belmonte JC. (2013) Autophagic control of cell 'stemness'. EMBO Mol Med 5(3):327-331.
  • Aguirre A, Sancho-Martinez I, Izpisua Belmonte JC. (2013) Reprogramming toward Heart Regeneration: Stem Cells and Beyond. Cell Stem Cell 12(3):275-84.
  • Sui L, Liu GH, Belmonte JC. (2013) Prospects on hESC-derived pancreatic progenitor expansion. Cell Res Feb 5. [Epub ahead of print].
  • Masuda S, Li M, Izpisua Belmonte JC. (2013) Niche-less maintenance of HSCs by 2i. Cell Res Jan 29. [Epub ahead of print].
  • Ruiz S, Gore A, Li Z, Panopoulos AD, Montserrat N, Fung HL, Giorgetti A, Bilic J, Batchelder EM, Zaehres H, Schöler HR, Zhang K, Izpisua Belmonte JC. (2013) Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming. Nat Commun 4: 1382.
  • Eguizabal C, Montserrat N, Veiga A, Izpisua Belmonte JC. (2013) Dedifferentiation, transdifferentiation, and reprogramming: future directions in regenerative medicine. Semin Reprod Med 31(1): 82-94.
  • Guan D, Zhang W, Zhang W, Liu GH, Belmonte JC. (2013) Switching cell fate, ncRNAs coming to play. Cell Death Dis 4: e464.
  • Sancho-Martinez I, Izpisua Belmonte JC. (2013) Stem cells: Surf the waves of reprogramming. Nature 493(7432): 310-1.
  • Berniakovich I, Laricchia-Robbio L, Izpisua Belmonte JC. (2012) N-acetylcysteine protects induced pluripotent stem cells from in vitro stress: impact on differentiation outcome. Int J Dev Biol 56(9): 729-35.
  • Nivet E, Sancho-Martinez I, Izpisua Belmonte JC. (2013) Conversion of pericytes to neurons: a new guest at the reprogramming convention. Stem Cell Res Ther 4(1): 2.
  • Martí M, Mulero L, Pardo C, Morera C, Carrió M, Laricchia-Robbio L, Esteban CR, Izpisua Belmonte JC. (2013) Characterization of pluripotent stem cells. Nat Protoc 8(2): 223-53
  • Masuda S, Izpisua Belmonte JC. (2012) The microenvironment and resistance to personalized cancer therapy. Nat Rev Clin Oncol Dec 18. [Epub ahead of print].
  • Izpisua Belmonte JC. (2012) Reprogramming development and aging: cell differentiation as a malleable process. Curr Opin Cell Biol 24(6): 713-5. [Epub ahead of print].
  • Zhang K, Yi F, Liu GH, Izpisua Belmonte JC. (2012) New march towards the regeneration of sensation and cognition: hear more, see more and learn more. J Mol Cell Biol Dec 6. [Epub ahead of print].
  • Leo Kurian, Ignacio Sancho-Martinez, Emmanuel Nivet, Aitor Aguirre, Krystal Moon, Caroline Pendaries, Cecile Volle-Challier, Francoise Bono, Jean-Marc Herbert, Julian Pulecio, Yun Xia, Mo Li, Nuria Montserrat, Sergio Ruiz, Ilir Dubova, Concepcion Rodriguez, Ahmet M Denli, Francesca S Boscolo, Rathi D Thiagarajan, Fred H Gage, Jeanne F Loring, Louise C Laurent & Juan Carlos Izpisua Belmonte. (2012) Conversion of human fibroblasts to angioblast-like progenitor cells. Nature Methods Dec 2. [Epub ahead of print].
  • Gu Y, Yi F, Liu GH, Belmonte JC. (2012) Beating in a dish: new hopes for cardiomyocyte regeneration. Cell Res Nov 27. [Epub ahead of print].
  • Mo Li, Juan Carlos Izpisua Belmonte. (2012) No factor left behind: generation of transgene-free induced pluripotent stem cells. Am J Stem Cells 1(1):75-80.
  • Okamura D, Maeda I, Taniguchi H, Tokitake Y, Ikeda M, Ozato K, Mise N, Abe K, Noce T, Izpisua Belmonte JC, Matsui Y. (2012) Cell cycle gene- specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev. 26(22): 2477-82.
  • Jopling C, Suñè G, Faucherre A, Fabregat C, Izpisua Belmonte JC. (2012) Hypoxia Induces Myocardial Regeneration in Zebrafish. Circulation Nov 14. [Epub ahead of print].
  • Yang SL, Harnish E, Leeuw T, Dietz U, Batchelder E, Wright PS, Peppard J, August P, Volle-Challier C, Bono F, Herbert JM, Belmonte JC. (2012) Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis. Protein Cell Nov 17. [Epub ahead of print].
  • Masuda S, Li M, Belmonte JC. (2012) In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK). Cell Res Oct 9. [Epub ahead of print].
  • Tiscornia G, Lorenzo Vivas E, Matalonga L, Berniakovich I, Barragán Monasterio M, Eguizábal Argaiz C, Gort L, González F, Mellet CO, García Fernández JM, Ribes A, Veiga A, Izpisua Belmonte JC. (2012) Neuronopathic Gaucher's Disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds. Human Molecular Genetics Oct 31. [Epub ahead of print].
  • Guang-Hui Liu, Jing Qu, Keiichiro Suzuki, Emmanuel Nivet, Mo Li, Nuria Montserrat, Fei Yi, Xiuling Xu, Sergio Ruiz, Weiqi Zhang, Ulrich Wagner, Audrey Kim, Bing Ren, Ying Li, April Goebl, Jessica Kim, Rupa Devi Soligalla, Ilir Dubova, James Thompson, John Yates III, Concepcion Rodriguez Esteban, Ignacio Sancho-Martinez & Juan Carlos Izpisua Belmonte. (2012) Generation Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature Oct 17. [Epub ahead of print].
  • Masuda S, Izpisua Belmonte JC. (2012) Trametinib for patients with advanced melanoma. Lancet Oncology (10): e409
  • Ruiz S, Panopoulos AD, Montserrat N, Multon MC, Daury A, Rocher C, Spanakis E, Batchelder EM, Orsini C, Deleuze JF, Izpisua Belmonte JC. (2012) Generation of a drug-inducible reporter system to study cell reprogramming in human cells.
    Journal of Biological Chemistry Sep 27. [Epub ahead of print]
  • Liu GH, Ding Z, Izpisua Belmonte JC. (2012) iPSC technology to study human aging and aging-related disorders.
    Current Opinion in Cell Biology Sep 18. [Epub ahead of print]
  • Ruiz, S, Diep, D, Goreb, A, Panopoulos, AD, Montserrat, N, Plongthongkumb, N, Kumara, S, Fung, HL, Giorgetti, A, Bilic, J, Batchelder, EM, Zaehres, H, Kan, NG, Schöler, HR, Mercola, M, Zhang, K, and Izpisua Belmonte JC. (2012)
    Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. PNAS Sep 18. [Epub ahead of print]
  • Yi F, Qu J, Liu GH, Belmonte JC. (2012) The dawn of angiogenesis modeling: regenerating vasculature from human pluripotent stem cells. Cell Res Sep 11. [Epub ahead of print]
  • Murphy DA, Diaz B, Bromann PA, Tsai JH, Kawakami Y, Maurer J, Stewart RA, Izpisúa-Belmonte JC, Courtneidge SA. (2012) Correction: A Src-Tks5 Pathway Is Required for Neural Crest Cell Migration during Embryonic Development. PLoS One 7(8)
  • Sancho-Martinez I, Baek SH, Izpisua Belmonte JC. (2012) Lineage conversion methodologies meet the reprogramming toolbox. Nat Cell Biol 14(9): 892-9
  • Montserrat N, Garreta Bahima E, Batlle L, Häfner S, Cavaco Rodrigues AM, González F, Izpisúa Belmonte JC. (2012) Erratum to: Generation of Pig iPS Cells: A Model for Cell Therapy. J Cardiovasc Transl Res. Aug 31. [Epub ahead of print]
  • Zhang K, Yi F, Liu GH, Belmonte JC. (2012) Huntington's disease: Dancing in a dish. Cell Res Aug 7. [Epub ahead of print]
  • Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte JC, Cashman J, Mercola M. (2012) Small Molecule-Mediated TGF-β Type II Receptor Degradation Promotes Cardiomyogenesis in Embryonic Stem Cells. Cell Stem Cell 11(2):242-52.
  • Li M, Liu GH, Izpisúa Belmonte JC. (2012) Navigating the epigenetic landscape of pluripotent stem cells. Nat Rev Mol Cell Biol 13(8): 524-35.
  • Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu GH, Gage FH, Izpisúa Belmonte JC. (2012) Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. PNAS Jul 18. [Epub ahead of print]
  • Yi F, Qu J, Li M, Suzuki K, Kim NY, Liu GH, Izpisúa Belmonte JC. (2012) Establishment of hepatic and neural differentiation platforms of Wilson's disease specific induced pluripotent stem cells. Protein Cell Jul 18. [Epub ahead of print]
  • Masuda S, Monserrat N, Okamura D, Suzuki K, Izpisúa Belmonte JC. (2012) Cardiosphere-derived cells for heart regeneration. Lancet 379(9835): 2425-6.
  • Arán B, Solé M, Rodriguez-Pizà I, Parriego M, Muñoz Y, Boada M, Barri PN, Izpisúa Belmonte JC, Veiga A. (2012) Vitrified blastocysts from Preimplantation Genetic Diagnosis (PGD) as a source for human Embryonic Stem Cell (hESC) derivation. J Assist Reprod Genet Jun 27. [Epub ahead of print]
  • Cai N, Li M, Qu J, Liu GH, Izpisúa Belmonte JC. (2012) Post-translational modulation of pluripotency. J Mol Cell Biol. Jun 7 [Epub ahead of print]
  • Christen B, Cavaco Rodrigues AM, Barragán Monasterio M, Fabregat Roig C, Izpisúa Belmonte JC. (2012) Transient downregulation of Bmp signalling induces extra limbs in vertebrates. Development Jun 6. [Epub ahead of print]
  • Barrero MJ, Berdasco M, Paramonov I, Bilic J, Vitaloni M, Esteller M, Izpisúa Belmonte JC. (2012) DNA Hypermethylation in Somatic Cells Correlates with Higher Reprogramming Efficiency. Stem Cells 30(8): 1696-702.
  • Gu Y, Liu GH, Izpisúa Belmonte JC. (2012) Gametogenesis in a dish. Cell Res. May 29 [Epub ahead of print]
  • Letamendia A, Quevedo C, Ibarbia I, Virto JM, Holgado O, Diez M, Izpisúa Belmonte JC, Callol-Massot C. (2012) Development and validation of an automated high-throughput system for zebrafish in vivo screenings. PLoS One 7(5): e36690.
  • Montserrat N, Ramirez-Bajo MJ, Xia Y, Sancho-Martinez I, Moya-Rull D, Miquel-Serra L, Yang S, Nivet E, Cortina C, Gonzalez F, Izpisúa Belmonte JC, Campistol JM. (2012) Generation of induced pluripotent stem cells from human renal proximal tubular cells with only two transcription factors: OCT4 and SOX2. J Biol Chem May 21. [Epub ahead of print]
  • Panopoulos AD, Izpisúa Belmonte JC. (2012) Induced pluripotent stem cells in clinical hematology: potentials, progress, and remaining obstacles. Curr Opin Hematol 19(4): 256-60.
  • Liu GH, Yi F, Suzuki K, Qu J, Izpisúa Belmonte JC. (2012) Induced neural stem cells: a new tool for studying neural development and neurological disorders. Cell Res. May 1. [Epub ahead of print]
  • Vassena R, Montserrat N, Canal BC, Aran B, de Oñate L, Veiga A, Izpisúa Belmonte JC. (2012) Accumulation of instability in serial differentiation and reprogramming of parthenogenetic human cells. Hum Mol Genet. Apr 30. [Epub ahead of print]
  • Xu X, Qu J, Suzuki K, Li M, Zhang W, Liu GH, Izpisúa Belmonte JC. (2012) Reprogramming based gene therapy for inherited red blood cell disorders. Cell Res. Apr 3. [Epub ahead of print]
  • Yi F, Liu GH, Izpisúa Belmonte JC. (2012) Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy. Protein Cell 3(4): 246-50.
  • Jopling C, Suñé G, Morera C, Izpisúa Belmote JC. (2012) p38α MAPK regulates myocardial regeneration in zebrafish. Cell Cycle 11(6): 1195-201. 
  • Liu GH, Li M, Qu J, Izpisúa Belmonte JC. (2012) Gating neural development and aging via nuclear pores. Cell Res Mar 13. [Epub ahead of print]
  • Yi F, Liu GH, Izpisúa Belmonte JC. (2012) Rejuvenating liver and pancreas through cell transdifferentiation. Cell Res Feb 28. [Epub ahead of print]
  • Cavaco Rodrigues AM, Christen B, Martí M, Izpisúa Belmonte JC. (2012) Skeletal muscle regeneration in Xenopus tadpoles and zebrafish larvae. BMC Dev Biol 12(1): 9.
  • Montserrat N, Aran B and Izpisúa Belmonte JC. (2012) Cellules Mare Embrionaries: Que en Sabem Despres de Trenta Anys D'Investigacio? Treballs de la SCB 63: 215-233.
  • Bilic J, Izpisúa Belmonte JC. (2012) Concise review: induced pluripotent stem cells versus embryonic stem cells: close enough or yet too far apart? Stem Cells 30(1): 33-41.
  • Liu G-H, Sancho-Martinez I, and Izpisúa Belmonte JC. (2012) Cut and Paste: restoring cellular function by gene correction. Cell Research 22(2): 283-4.
  • Menendez S, Camus S, Herreria A, Paramonov I, Batlle Morera L, Collado M, Pekarik V, Maceda I, Edel M, Consiglio A, Sanchez A, Li H, Serrano M, Izpisúa Belmonte JC. (2012) Increased dosage of tumor suppressors limits the tumorigenicity of iPS cells without affecting their pluripotency. Aging Cell 11(1): 41-50.
  • Panopoulos AD, Yanes O, Ruiz S, Kida YS, Diep D, Tautenhahn R, Herrerías A, Batchelder EM, Plongthongkum N, Lutz M, Berggren WT, Zhang K, Evans RM, Siuzdak G, Izpisúa Belmonte JC. (2012) The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. Cell Res 22(1): 168-77.
  • Sanchez-Danes A, Consiglio A, Richaud Y, Rodriguez-Piza I, Dehay B, Edel M, Bove J, Memo M, Vila M, Raya A, Izpisua Belmonte JC. (2012) Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and iPS cells. Human Gene Therapy 23(1): 56-69.
  • Fütterer A, Raya A, Llorente M, Izpisúa-Belmonte JC, de la Pompa JL, Klatt P, Martínez-A C. (2012) Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development. Cell Death Differ 19(1):132-43.
  • Camus S, Quevedo C, Menéndez S, Paramonov I, Stouten PF, Janssen RA, Rueb S, He S, Snaar-Jagalska BE, Laricchia-Robbio L, Izpisúa Belmonte JC. (2011) Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish. Oncogene, Dec 19. [Epub ahead of print]
  • Tiscornia G, Lorenzo Vivas E, Izpisúa Belmonte JC. (2011) Diseases in a Dish: modeling human disease with induced pluripotent stem cells. Nature Medicine Dec 6: 1570-1576.
  • Li M, Suzuki K, Qu J, Saini P, Dubova I, Yi F, Lee J, Sancho-Martinez I, Liu GH, Izpisúa Belmonte JC. (2011) Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs. Cell Res 21(12): 1740-4.
  • Sancho-Martinez I, Nivet E, Izpisúa Belmonte JC. (2011) The labyrinth of nuclear reprogramming. J Mol Cell Biol 3(6): 327-9.
  • Sancho-Martinez I, Nivet E, Izpisúa Belmonte JC. (2011) Purging and isolating pluripotent cells, "sweet" dreams become true? Cell Res 21(11): 1526-7.
  • Montserrat N, de Oñate L, Garreta E, González F, Adamo A, Eguizábal C, Häfner S, Vassena R, Izpisúa Belmonte JC. (2011) Generation of feeder free pig induced pluripotent stem cells without Pou5f1. Cell Transplant, Sep 23. [Epub ahead of print]
  • Yasuhiko Kawakami, Merce Marti, Hiroko Kawakami, Junji Itou, Thu Quach, Austin Johnson, Setsuko Sahara, Dennis D. M. O’Leary, Yasushi Nakagawa, Mark Lewandoski, Samuel Pfaff, Sylvia M. Evans and Juan Carlos Izpisúa Belmonte. (2011) Islet1-mediated activation of the beta-catenin pathway is necessary for hindlimb initiation in mice. Development 138: 4465-4473.
  • Adamo A, Barrero MJ, Izpisúa Belmonte JC. (2011) LSD1 and pluripotency: A new player in the network. Cell Cycle 10(19): 3215-6.
  • Terme JM, Sese B, Millan-Arino L, Mayor R, Izpisúa Belmonte JC, Barrero MJ, Jordan A. Histone H1 variants are differentially expressed and incorporated into chromatin during differentiation and reprogramming to pluripotency. J Biol Chem 286(41): 35347-57.
  • Panopoulos AD, Izpisúa Belmonte JC. (2011) Anaerobicizing into pluripotency. Cell Metab 14(2): 143-4.
  • Danielle A. Murphy, Begoña Diaz, Paul A. Bromann, Jeff H. Tsai, Yasuhiko Kawakami, Jochen Maurer, Rodney A. Stewart, Izpisúa Belmonte JC, Sara A. Courtneidge. (2011) A Src-Tks5 Pathway Is Required for Neural Crest Cell Migration during Embryonic Development. PLoS ONE 6(7): e22499.
  • Rita Vassena, Stéphanie Boué, Eva González-Roca, Begoña Aran, Herbert Auer, Anna Veiga and Izpisúa Belmonte JC (2011) Waves of early transcriptional activation and pluripotency program initiation during human preimplantation development. Development 138(17): 3699-709.
  • Eguizabal C, Montserrat N, Vassena R, Barragan M, Garreta E, Garcia-Quevedo L, Vidal F, Giorgetti A, Veiga A, Izpisúa Belmonte JC. (2011) Complete Meiosis from Human Induced Pluripotent Stem Cells. Stem Cells 29(8):1186-95.
  • Liu GH, Suzuki K, Qu J, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring JF, Laurent LC, Izpisúa Belmonte JC. (2011) Targeted Gene Correction of Laminopathy-Associated LMNA Mutations in Patient-Specific iPSCs. Cell Stem Cell 8(6): 688-94.
  • Adamo A, Sesé B, Boue S, Castaño J, Paramonov I, Barrero MJ, Izpisúa Belmonte JC. (2011) LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells. Nat Cell Biol 13(6): 652-60. 
  • Athanasia D. Panopoulos, Sergio Ruiz, Fei Yi, Aída Herrerías, Erika M. Batchelder, Izpisúa Belmonte JC. (2011) Rapid and Highly Efficient Generation of Induced Pluripotent Stem Cells from Human Umbilical Vein Endothelial Cells. PLoS ONE May, 6(5): e19743.
  • Giorgetti, A., Fazzina, R., Li, M. and Izpisúa Belmonte, JC. (2011) Human cord blood reprogrammed into embryonic-like stem cells. ISBT Science Series 6: 107-111.
  • Woods NB, Parker AS, Moraghebi R, Lutz MK, Firth AL, Brennand KJ, Berggren WT, Raya A, Izpisúa Belmonte JC, Gage FH, Verma IM. (2011) Brief report: Efficient Generation of Hematopoietic Precursors and Progenitors From Human Pluripotent Stem Cell Lines. Stem Cells 29(7): 1158-64.
  • Robles V, Martí M, Izpisúa Belmonte JC. Study of Pluripotency Markers in Zebrafish Embryos and Transient Embryonic Stem Cell Cultures. Zebrafish 8(2): 57-63.
  • Barrero MJ, Izpisúa Belmonte JC. (2011) iPS cells forgive but do not forget. Nat Cell Biol, 13(5): 523-5.
  • Menchón C, Edel MJ, Izpisúa Belmonte JC. (2011) The cell cycle inhibitor p27Kip1 controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist. Cell Cycle 10(9): 1435-47.
  • Edel MJ, Menchon C, Andres Vaquero JM, Izpisúa Belmonte JC. (2011) A protocol to assess cell cycle and apoptosis in human and mouse pluripotent cells. Cell Commun Signal. Apr 11 9(1): 8.
  • Panopoulos AD, Ruiz S, Izpisúa Belmonte JC. (2011) iPSCs: Induced Back to Controversy. Cell Stem Cell, Apr 8 8(4): 347-8.
  • Tiscornia G, Monserrat N, Izpisúa Belmonte JC. (2011) Modelling Long QT Syndrome With iPS Cells: Be Still, My Beating Heart ... Circ Res, Mar 18, 108(6): 648-9.
  • Sancho-Martinez I, Li M, Izpisúa Belmonte JC. (2011) Disease Correction the iPSC Way: Advances in iPSC-Based Therapy. Clin Pharmacol Ther 89(5): 746-9.
  • Kim S, Izpisúa Belmonte JC. (2011) Pluripotency of male germline stem cells. Mol Cells 32(2): 113-121.
  • Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisúa Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. (2011) Somatic coding mutations in human induced pluripotent stem cells. Nature 471 (7336): 63-7.
  • Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Iii JY, Izpisúa Belmonte JC. (2011) Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature Apr 14, 472(7342): 221-5.
  • González F, Boué S, Izpisúa Belmonte JC. (2011) Methods for making induced pluripotent stem cells: reprogramming à la carte. Nat Rev Genet 12(4): 231-42.
  • Barrero MJ, Izpisúa Belmonte JC. (2011) Regenerating the epigenome. EMBO Rep. 12(3): 208-15.
  • Montserrat N, Garreta Bahima E, Gonzalez F, Gutierrez J, Eguizabal C, Ramos Perez V, Borros S, Izpisua Belmonte JC. (2011) Simple generation of human induced Pluripotent stem cells using Poly({beta}-Amino Esters) as non-viral gene delivery system. J Biol Chem 286(14): 12417-28.
  • Chris Jopling, Stephanie Boue & Izpisúa Belmonte JC. (2011) Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nature Reviews Molecular Cell Biology 12, 79-89.
  • Li M, Sancho-Martinez I, Izpisúa Belmonte JC. (2011) Cell fate conversion by mRNA. Stem Cell Res Ther. 2(1): 5.
  • Isao Oishi, Sungtae Kim, Kyoko Yoshi, Concepcion Rodriguez Esteban and Izpisua Belmonte JC. (2011) Cre-LoxP-regulated expression of monoclonal antibodies driven by an ovalbumin promoter in primary oviduct cells. BMC Biotechnology, Jan 14 11(1): 5.
  • Montserrat N, Bahima EG, Batlle L, Häfner S, Rodrigues AM, González F, Belmonte JC. (2011) Generation of Pig iPS Cells: A Model for Cell Therapy. J Cardiovasc Transl Res 4(2): 121-30.
  • Louise C. Laurent, Igor Ulitsky, Ileana Slavin, Ha Tran, Andrew Schork, Robert Morey, Candace Lynch, Julie V. Harness, Sunray Lee, Maria J. Barrero, Sherman Ku, Marina Martynova, Ruslan Semechkin, Vasiliy Galat, Joel Gottesfeld, Izpisúa Belmonte JC, Chuck Murry, Hans S. Keirstead, Hyun-Sook Park, Uli Schmidt, Andrew L. Laslett, Franz-Josef Muller, Caroline M. Nievergelt, Ron Shamir, and Jeanne F. Loring. (2011) Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture. Cell Stem Cell 8, 106–118.
  • Ruiz S, Panopoulos AD, Herrerías A, Bissig KD, Lutz M, Berggren WT, Verma IM, Izpisúa Belmonte JC. (2011) A High Proliferation Rate Is Required for Cell Reprogramming and Maintenance of Human Embryonic Stem Cell Identity. Curr Biol, Jan 1121(1): 45-52.
  • Tiscornia G and Izpisúa Belmonte JC. (2010) MicroRNAs in embryonic stem cell function and fate. Genes Dev Dec 15, 24(24): 2732-41.
  • Ruiz S, Brennand K, Panopoulos AD, Herrerias A, Gage FH, Izpisúa Belmonte JC. (2010) High-Efficient Generation of Induced Pluripotent Stem Cells from Human Astrocytes. PLoS ONE Dic; 5(12): e15526.
  • Barrero MJ, Boué S, Izpisúa Belmonte JC. (2010) Epigenetic Mechanisms that Regulate Cell Identity. Cell Stem Cell, Nov 5, 7(5): 565-70.
  • Menendez S, Camus S, Izpisúa Belmonte JC. (2010) p53: Guardian of reprogramming. Cell Cycle, Oct 1 9(19):3887-91. 
  • Pere Santamaria, Ignacio Rodríguez-Pizá, Xavier Clemente-Casares, Jun Yamanouchi, Lola Mulero-Perez, Trond Aasen, Angel Raya, Izpisúa Belmonte JC. (2010) Turning Human Epidermis Into Pancreatic Endoderm. Rev Diabet Stud, 7(2): 151-160.
  • Boué S, Paramonov I, Barrero MJ, Izpisúa Belmonte JC. (2010) Analysis of Human and Mouse Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells. What Is in the Plate? PLoS ONE Sep 17; 5(9). pii: e12664.
  • Montserrat N, Jopling C, Izpisúa Belmonte JC. (2010) Understanding the molecular basis for cardiomyocyte cell cycle regulation: new insights in cardiac regeneration after injury? Expert Rev Cardiovasc Ther, Aug 8(8): 1043-5.
  • Masip M, Veiga A, Izpisúa JC, Simón C. (2010) Reprogramming with defined factors: from induced pluripotency to induced transdifferentiation. Mol Hum Reprod 16: 856-868.
  • Bayes-Genis, A., Soler-Botija, C., Farre, J., Sepulveda, P., Raya, A., Roura, S., Prat-Vidal, C., Galvez, C., Anastasio Montero, J., Buscher, D. and Izpisua Belmonte, JC. (2010) Identification of a novel progenitor cell population from adult human cardiac adipose tissue with potential for cardiac repair. Journal of Molecular and Cellular Cardiology 49: 771-780.
  • Isaacs MJ, Kawakami Y, Allendorph GP, Yoon B, Izpisúa Belmonte JC, and Choe S. (2010) Bone morphogenetic protein-2 and -6 heterodimer illustrates the nature of ligand-receptor assembly. Molecular Endocrinology, Jul 24(7): 1469-77.
  • Edel, M. and Izpisúa Belmonte, JC. (2010) The cell cycle and pluripotency: Is there a direct link? Cell Cycle 9: 2694-2695.
  • Valera E, Isaacs MJ, Kawakami Y, Izpisúa Belmonte JC, Choe S. (2010) BMP-2/6 heterodimer is more effective than BMP-2 or BMP-6 homodimers as inductor of differentiation of human embryonic stem cells. PLoS One Jun 17; 5(6): e11167.
  • Sleep E, Boué S, Jopling C, Raya M, Raya A, Izpisúa Belmonte, JC. (2010) Transcriptomics approach to investigate zebrafish heart regeneration. J Cardiovasc Med (Hagerstown) May, 11(5): 369-80.
  • Giorgetti A, Montserrat N, Rodriguez-Piza I, Azqueta C, Veiga A, Izpisúa Belmonte, JC. (2010) Generation of induced pluripotent stem cells from human cord blood cells with only two factors: Oct4 and Sox2. Nature Protocols 5(4): 811-20.
  • Raya, A, Rodriguez-Piza, I, Navarro, S, Richaud, Y, Guenechea, G, Sanchez-Danes, A, Consiglio, A, Bueren, J and Izpisúa Belmonte, JC. (2010) A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells. Nature Protocols 5(4): 647-60.
  • Chris Jopling, Eduard Sleep, Marina Raya, Mercè Martí, Angel Raya & Izpisúa Belmonte JC. (2010) Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature Mar 25; 464 (7288): 606-9.
  • Michael J. Edel, Cristina Menchón, Sergio Menéndez, Antonella Consiglio, Angel Raya, and Izpisúa Belmonte JC. (2010) Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1. Genes Dev 24: 561-573.
  • Sugii S, Kida Y, Kawamura T, Suzuki J, Vassena R, Yin YQ, Lutz MK, Berggren WT, Izpisúa Belmonte JC, Evans RM. (2010) Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells. Proc Natl Acad Sci U S A. Feb 23, 107(8): 3558-63.
  • Christen, B, Robles, V, Raya, M, Paramonov, I and Izpisúa Belmonte JC. (2010) Regeneration and reprogramming compared. BMC Biol. Jan 20; 8:5.
  • Shigeki Sugiia, Yasuyuki Kida, Teruhisa Kawamura, Jotaro Suzuki, Rita Vassena, Yun-Qiang Yin, Margaret K. Lutz, W. Travis Berggren, Izpisúa Belmonte JC, and Ronald M. Evans. (2010) Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells. PNAS Feb 23; 107(8): 3558-63.
  • Aasen, T. and Izpisúa Belmonte JC. (2010) Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nature Protocols 5(2): 371-82.
  • Tramullas, M., Diaz, A., San-Emeterio, E.P., Morchon, N., Lantero, A., Merino, D., Buscher, D., Merino, R., Hurle, J.M., Izpisúa Belmonte JC and Hurle, M. (2010) BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation. Journal of Neuroscience Jan 27; 30(4): 1502-11.
  • Mizrak, S.C., Chikhovskaya, J.V., Sadri-Ardekani, H., van Daalen, S., Korver, C.M., Hovingh, S.E., Roepers-Gajadien, H.L., Raya, A., Fluiter, K., de Reijke, Th.M., de la Rosette, J.J.M.C.H., Izpisúa Belmonte JC, van der Veen, F., de Rooij, D.G. and van Pelt, A.M.M. (2010) Embryonic Stem Cell-like Cells Derived from Adult Human Testis. Human Reproduction, Jan 25(1): 158-67.
  • Rodriguez-Piza, I., Richaud-Patin, Y., Vassena, R., Gonzalez, F., Barrero, M.J., Veiga, A., Raya, A. and Izpisúa Belmonte JC. (2010) Reprogramming of human fibroblasts to induced pluripotent stem cells under xeno-free conditions. Stem Cells, Jan 28(1): 36-44.
  • Ibanes, M. and Izpisúa Belmonte JC. (2009) Left-right asymmetry determination. Wiley Interdisciplinary Reviews: Systems Biology and Medicine. Sept/Oct: 210-219.
  • Aran B, Rodriguez-Pizà I, Raya A, Consiglio A, Muñoz Y, Barri PN, Izpisúa Belmonte JC, Veiga A. (2010) Derivation of human embryonic stem cells at the Center of Regenerative Medicine in Barcelona. In Vitro Cellular & Developmental Biology - Animal, Apr 46(3-4): 356-66.
  • B.Aran, A.Veiga, Izpisúa Belmonte JC. (2009) Células madre pluripotentes Revista Arbor. In press.
  • Stewart, S., Tsun, Z.Y. and Izpisúa Belmonte JC. (2009) A histone demethylase is necessary for regeneration in zebrafish. PNAS  106(47):  19889-19894.
  • Giorgetti, A., Montserrat, N., Aasen, T., Rodriguez-Piza, I., Vassena, R., Gonzalez, F., Boue, S., Barrero, M.J., Aran Corbella, B., Raya, A., Torrebadella, M., Veiga, A. and Izpisúa Belmonte JC. (2009) Generation of induced pluripotent stem cells from cord blood using OCT4 and SOX2. Cell Stem Cell. 5:353-357.
  • Izpisúa Belmonte JC, Ellis, J., Hochedlinger, K. and Yamanaka, S. (2009) Induced pluripotent stem cells and reprogramming: seeing the science through the hype. Nature Reviews Genetics 10: 878-883.
  • Kawamura, T., Suzuki, J., Wang, Y.V., Menendez, S., Batlle, L., Wahl, G. and Izpisúa Belmonte JC. (2009) Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460: 1140-1144.
  • Kan, N., Junghans, D. and Izpisúa Belmonte JC. (2009) Compensatory growth mechanisms regulated by BMP and FGF signaling pathways mediate liver regeneration in zebrafish after partial hepatectomy. FASEB 23: 3516-3525.
  • Raya, A., Rodriguez-Piza, I., Guenechea, G., Vassena, R., Navarro, S., Barrero, M.J., Consiglio, A., Rio, P., Sleep, E., Tiscornia, G., Garreta, E., Aasen, T., Veiga, A., Verma, I., Bueren, J. and Izpisúa Belmonte JC. (2009) Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460 (7251): 53-9.
  • Kelber, J.A., Panopoulos, A.D., Shani, G., Booker, E.C., Izpisúa Belmonte JC, Vale, W.W. and Gray, P.C. (2009) Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPk/PI3K and Smad2/3 pathways. Oncogene 28: 2324-2336.
  • Gonzalez, F., Barragan Monasterio, M., Tiscornia, G., Montserrat Pulido, N., Vassena, R., Batlle Morera, L., Rodriguez Piza, I. and Izpsiua Belmonte JC. (2009) Generation of mouse induced pluripotent stem cells by transient expression of a single non-viral polycistronic vector. PNAS 106(22): 8918-8922.
  • Beck, C., Izpisúa Belmonte JC and Christen, B. (2009) Beyond Early Development: Xenopus as an emerging model for the study of regenerative mechanisms. Developmental Dynamics. 238(6): 1226-48.
  • Jopling, C. and Izpisúa Belmonte JC. (2009) Cilia-Where Two Wnts Collide. Zebrafish 6(1): 15-19.
  • Fink, M., Chu, A., Ruiz-Lozano, P., Callol, C., Izpisúa Belmonte JC, Giles, W., Bodmer, R. and Ocorr, K. (2009) A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques 46: 101-113.
  • Rojas-Muñoz, A., Rajadhyksha, S., Gilmour, D., van Bebber, F., Rodríguez-Esteban, C., Nüsslein-Volhard, C., & Izpisúa Belmonte JC. (2009) ErbB2 and ErbB3 regulate amputation-induced proliferation and migation during vertebrate regeneration. Developmental Biology 327: 177-190.
  • Raya, A., Rodriguez-Piza, I., Aran, B., Consiglio, A., Barri, P., Veiga, A., and Izpisúa Belmonte JC. (2009) Generation of cardiomyocytes from new human embryonic stem cell lines derived from poor-quality blastocysts. 73rd Cold Spring Harbor Laboratory Symposium. 73:1-9.
  • Raya, A and Izpisúa Belmonte JC. (2009) Stem Cell Research in Spain: If Only They Were Windmills. Cell Stem Cell 4(6): 483-486.
  • Kawakami, Y., Uchiyama, Y., Rodriguez Esteban, C., Toshiaki, I., Kawakami, H., Marti, M., Kmita, M., Monaghan-Nicols, P., Nishinakamura, R. and Izpisúa Belmonte JC. (2008) Sall genes regulate region specific morphogenesis in the limb by modulating Hox activities. Development 136: 585-594.
  • Stubbs, J., Oishi, I., Izpisúa Belmonte JC and Kintner, C. (2008) The Forkhead protein, FoxJ1, specified node-like cilia in Xenopus and Zebrafish embryos. Nature Genetics. 40:1454-1460.
  • Ibanes, M. and Izpisúa Belmonte JC. (2008) Left-right asymmetry determination. Wiley Interdisciplinary Reviews: Systems Biology and Medicine. In Press.
  • Aasen, T., Raya, A., Barrero, M.J., Garreta, E., Consiglio, A., Gonzalez, F., Vassena, R., Bilic, J., Pekarik, V., Tiscornia, G., Edel, M., Boue, S. and Izpisúa Belmonte JC. (2008) Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nature Biotechnology. 26:1276-1284.
  • Raya, A. and Izpisúa Belmonte JC. (2008) Insights into the establishment of left-right asymmetries in vertebrates. BDRC: Embryo Today. 84(2):81-94.
  • Ibanes, M and Izpisúa Belmonte JC. (2008) Theoretical and experimental approaches to understand morphogen gradients. Nature Molecular Systems Biology. 4:176.
  • Pekarik, V. and Izpisúa Belmonte JC. (2008) NFIX-One Gene, Two Knockouts, Multiple Effects. Journal of Biology. 7:29.
  • Kurpios, N.A., Ibanes, M., Davis, N.M., Lui, W., Katz, T., Martin, J.F., Izpisúa Belmonte JC and Tabin, C.J. (2008) Directional gut looping is mediated by changes in the extracellular matrix and in cell:cell adhesion. PNAS. 105:8499-8506.
  • Moreno, T.A., Jappelli, R., Brenner, S., Izpisúa Belmonte JC, and Kintner, C. (2008) Retinoic Acid Regulation of the Mesp-Ripply Feedback Loop During Vertebrate Segmental Patterning. Developmental Biology. 315:317-330.
  • Suzuki, A., Sayaka, S., Buscher, D., Izpisúa Belmonte JC, and Taniguchi, H. (2008) Tbx3 controls hepatic stem cell fate in liver development by suppressing p19ARF expression. Development. 135:1589-1595
  • Garcia-Gonzalo, F.R. and Izpisúa Belmonte JC. (2008) Albumin-associated Lipids Regulate Human Embryonic Stem Cell Self-Renewal. PLoS ONE, Jan 2; 3(1): e1384.
  • Rodríguez-León J, Rodríguez Esteban C, Martí M, Santiago-Josefat B, Dubova I, Rubiralta X, Izpisúa Belmonte JC. (2008) Pitx2 regulates gonad morphogenesis. PNAS 105(32):11242-7.
  • Barrero, M.J. and Izpisua Belmonte J.C. (2008) Epigenetic Mechanisms Controlling Mesodermal Specification. StemBook, doi/10.3824/stembook.1.9.1 StemBook, ed (Harvard)
  • Allendorph, G.P., Isaacs, M.J., Kawakami, Y., Izpisúa Belmonte JC, Choe, S. (2007) BMP-3 and BMP-6 Structures Illuminate the Nature of Binding Specificity with Receptors. Biochemistry. 46:12238-12247.
  • Stewart, S., Rojas-Munoz, A., and Izpisúa Belmonte JC. (2007) Bioelectricity and epimorphic regeneration. Bioessays. 29(11):1133-1137.
  • Sahara, S., Kawakami, Y., Izpisúa Belmonte JC, O'Leary, D.D.M. (2007) Dual roles of Sp8 on cortical area patterning for anterior or posterior identities. Neuronal Development, 2:10.
  • Ribeiro, R., Kawakami, Y., Buscher, D., Raya, A., Rodriguez-Leon, J., Morita, M., Rodriguez Esteban, C., Izpisúa Belmonte JC. (2007) Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart regionalization and looping. PLoS One, Apr 25; 2(4): e398.
  • Rojas-Munoz, A., Bernad Miana, A., and Izpisúa Belmonte JC. (2007) El pez cebra:la navaja suiza de la biologia. Investigacion y Ciencia. 366:62-69.
  • Zuzarte-Luis, V., Montero, J.A., Kawakami, Y., Izpisúa Belmonte JC, and Hurle, J. (2007) Lysosomal cathepsins in embryonic programmed cell death. Developmental Biology. 301:205-217.
  • Matsui, T., Raya, A., Callol, C., Kawakami, Y., Oishi, I., Rodriguez-Esteban, C., and Izpisúa Belmonte JC. (2007) Miles apart-mediated regulation of cell-Fibronectin interaction is required for proper myocardial migration in zebrafish. Nature Clinical Practice Cardiovascular Medicine. 4:S77-S82.
  • Kawakami, Y., Rodriguez Esteban, C., Raya, M., Kawakami, H., Marti, M., Dubova, I., and Izpisúa Belmonte JC. (2006) Wnt/ß-catenin signaling regulates vertebrate limb regeneration. Genes and Development. 20:3232-3237.
  • Kawakami, Y., Rodriguez-Leon, J., Izpisúa Belmonte JC. (2006) The role of TGFßs and Sox9 during limb chondrogenesis. Current Opinion in Cell Biology. 18:723-729.
  • Oishi, I., Kawakami, Y., Raya, A., Callol-Massot, C., Izpisúa Belmonte JC. (2006) Regulation of primary cilia formation and left-right patterning in zebrafish by duboraya, a novel mediator of non-canonical Wnt signaling. Nature Genetics. 38:1316-1322.
  • Ibanes, M., Rasskin-Gutman, D., Kawakami, Y., and Izpisúa Belmonte JC. (2006) Cell lineage transport: a mechanism for molecular gradient formation. Nature Molecular Systems Biology. 2:57.
  • Suzuki, A.,Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H.,Rodriguez-Esteban, C., and Izpisúa Belmonte JC. (2006) Nanog binds to Smad1and blocks BMP-induced differentiation of embryonic stem cells. PNAS 103: 10294-10299.
  • Soler-Botija,C., Cervera, R.P., Oishi, I., Raya, R.M., Dubova, I., Rodriguez-Esteban, C., Izpisúa Belmonte JC. (2006) Understanding embryonic heart development as atool for cardiac cell based therapy. Annals of Pediatrics 64: 15-22.
  • Weninger,W.J., Geyer, S.H., Mohun, T.J., Rasskin-Gutman, D., Matsui, T., Ribeiro, I.,Costa, L., Izpisúa Belmonte JC, Muller, G. B. (2006) High resolutionepiscopic microscopy: a rapid technique for high detailed 3D analysis of geneactivity in the context of tissue architecture and morphology. Anatomy and Embryology 211: 213-221.
  • Raya, A., Izpisúa Belmonte JC. (2006) Vertebrate left-right asymmetry: a convergence ofdivergences. Nature Reviews Genetics 7: 283-293.
  • Suzuki, A.,Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H.,Rodriguez-Esteban, C., Izpisúa Belmonte JC. (2006) Maintenance of embryonicstem cell pluripotency by Nanog-mediated reversal of mesoderm specification. Nature Clinical Practice Cardiovascular Medicine 3: S114-S122.
  • Merki, E., Zamora, M., Raya, A., Kawakami, Y., Zhang, X., Burch, J., Kubalak, S., Kaliman, P., Izpisúa Belmonte JC, Chien, K., Ruiz-Lozano, P. (2005) Epicardial RXRa is required for myocardial growth and coronary artery formation. PNAS 102: 18455-18460.
  • Leusch, H., Chanda,S.K., Raya, R.M., DeJesus, P.D., Orth, A.P. Walker, J.R., Izpisúa Belmonte JC, Schultz, P. (2006) A functional genomics approach to the mode of actionof apratoxin A. Nature Chemical Biology 2: 158-167.
  • Okada, Y.,Takeda, S., Tanaka Y., Izpisúa Belmonte JC, and Hirokawa, N. (2005) Mechanism of Ciliated Organ Flow: a Conserved Symmetry Breaking Event inLeft-Right Axis Determination. Cell 121: 633-644.
  • Kawakami,Y., Raya, A., Raya, R.M., Rodriguez-Esteban, C., Izpisúa Belmonte JC. (2005). Retinoic acid signaling links left-right asymmetric patterning andbilaterally symmetric somitogenesis in the zebrafish embryo. Nature May 12; 435(7039): 165-71.
  • Correa, R.,Matsui, T., Tergaonkar, V., Rodriguez-Esteban, C., Izpisúa Belmonte JC, Verma, I. (2005) Zebrafish IkB kinase 1 (Ikk1) negatively regulates NF-kBactivity. Current Biology 15: 1291-1295.
  • Da FontouraCosta, L., Travencolo, B.A.N., Azeredo, A., Beletti, M.E., Rasskin-Gutman, D.,Sternik, G., Izpisúa Belmonte JC, Ibanes, M., and Muller, G. (2005) A NovelFiel Approach to 3D Gne Expression Pattern Characterization. Applied PhysicsLetters 86: 143901-143903.
  • Francisco-Morcillo,J., Sanchez-Calderon, H., Kawakami, Y., Izpisúa Belmonte JC, Hidalgo-Sanchez, M., Martin-Partido, G. (2005) Expression of Fgf19 in thedeveloping eye. Developmental Brain Research 156: 104-109.
  • Kawakami,Y., Tsuda, M., Takahashi, S., Taniguchi, N., Rodriguez-Esteban, C., Zemmyo, M.,Furumatsu, T., Lotz, M., Izpisúa Belmonte JC and Asahara, H. (2005). Transcriptional co-activator PGC-1 regulates chondrogenesis via associationwith Sox 9. PNAS 102: 2414-2419.
  • Matsui, T.,Raya, A., Kawakami, Y., Callol, C., Capdevila, J., Rodriguez-Esteban, C., and Izpisúa Belmonte JC. (2005) Non-canonical Wnt signaling regulates midlineconvergence of organ primordia during zebrafish development. Genes and Development 19: 164-175.
  • Buceta, J., Ibanes, M., Rasskin-Gutman,D., Okada, Y., Hirokawa, N., and Izpisúa Belmonte JC. (2005). Nodal CiliaDynamics and the Specification of the Left/Right Axis in Early EmbryoDevelopment. Biophysical Journal 89: 2199-2209.
  • Rasskin-Gutman, D. and Izpisúa Belmonte JC. (2004) Embryos at the core of life, Development 130: 5564-5566.
  • Raya, A., Consiglio, A., Kawakami, Y.,Rodriguez-Esteban, C., and Izpisúa Belmonte JC. (2004) The zebrafish asa model of heart regeneration. Cloning and Stem Cells 6(4): 345-351.
  • Kawakami, Y., Rodriguez Esteban, C.,Matsui, T., Rodriguez-Leon, J., Kato, S. and Izpisúa Belmonte JC. (2004) Sp8 and Sp9 regulate Fgf8 expression and limb outgrowth in vertebrateembryos. Development 31: 4763-4774.
  • Raya, A. and Izpisúa Belmonte JC. (2004) Unveiling the establishment of left-rightasymmetry in the chick embryo. Mech. Dev 121: 1043-1054.
  • Kang, J.S., Oohashi, T., Kawakami, Y.,Bekku, Y., Izpisúa Belmonte JC and Ninomiya, Y. (2004) Characterization ofdermacan, a novel zebrafish lectican gene, expressed in dermal bones. Mechanismsof Development 121(3): 301-312.
  • Huang Q, Raya A, DeJesus P, Chao SH,Quon KC, Caldwell JS, Chanda SK, Izpisúa Belmonte JC, Schultz PG. (2004) Identification of p53 regulators by genome-wide functional analysis. Proc. Natl. Acad. Sci. USA 101(10): 3456-3461.
  • Correa, R.,Tergaonkar, V., Ng, J., Izpisúa Belmonte JC, and Verma, I. (2004) Notochorddifferentiation by the T-box gene ntl in zebrafish is regulated by NFkb. Molecular Cell Biology 24(12): 5257-5268.
  • Raya, A. and Izpisúa Belmonte JC. (2004) Sequential transfer of left-rightinformation during vertebrate embryo development. Curr. Op. Genes and Development 14: 575-581.
  • Rasskin-Gutman, D. and Izpisúa Belmonte JC. (2004) Theoretical morphology developmentalasymmetries. BioEssays  26(4): 405-412.
  • Saez, E., Rosenfeld, J., Livolsi, A.,Lombardo, E., Olson, P., Nelson,M., Banayo, E., Cardiff, R.D., Izpisúa Belmonte JC and Evans, R.M. (2004) PPARg signaling exacerbates mammary gland tumor development. Genes and Development 18(5): 528-540.
  • Timmerman, L.A., Grego-Bessa, J.,Bertrán, E., Pérez-Pomares, J.M., Diez, J., Aranda, S., Palomo, S., Raya, A., McCormick, F., Izpisúa Belmonte JC and de la Pompa, J.L. (2004) Notchpromotes epithelial-mesenchymal transitions during heart development andtransformation. Genes and Development 18(1): 99-115.
  • Raya, A., Kawakami, Y., Rodriguez-Esteban,C., Ibañes, M., Rasskin-Gutman, D., Rodriguez-León, J., Büscher, D., Feijó, J.A. and Izpisúa Belmonte JC. (2004) Notch activity acts as asensor for extracellular calcium during vertebrate left-rightdetermination. Nature 427: 121-128.
  • Raya, A., Koth, C.M., Büscher, D.,Kawakami, Y., Itoh, T., Raya, R.M., Sternik, G., Tsai, H.-J., Rodriguez-Esteban, C. and Izpisúa Belmonte JC. (2003) Activation of Notchsignaling pathway precedes heart regeneration in zebrafish. Proc. Natl.Acad. Sci. USA, Special Supplement on Stem Cells and the Future of Regenerative Medicine 100: 11889-11895.
  • Groppe, J., Greenwald, J., Wiater, E.,Rodriguez-Leon, J., Economides, A.N., Kwiatkowski, W., Baban, K., Affolter, M., Vale, W.W., Izpisúa Belmonte JC and Choe, S. (2003) Structural basis ofBMP signaling inhibition by Noggin, a novel twelve-membered cystine knotprotein. The Jnl. of Bone and Joint Surgery 85-A, Suppl. 3: 52-58.
  • Raya, A., Kawakami, Y.,Rodriguez-Esteban, C., Büscher, D., Koth, C.M., Itoh, T., Morita, M.,Raya, R.M., Dubova, I., Grego Bessa, J., de la Pompa, J.L. and Izpisúa Belmonte JC. (2003) Notch activity induces Nodal expression andmediates the establishment of left-right asymmetry in vertebrate embryos. GenesDev. 17: 1213-1218.
  • Kawakami, Y., Rodriguez-Leon, J., Koth,C.M., Büscher, D., Itoh, T., Raya, A., Ng, J.K., Rodriguez Esteban, C.,Takahashi, S., Henrique, D., Schwarz, M.F., Asahara, H. and Izpisúa Belmonte JC. (2003) MKP3 mediates the cellular response to FGF8signalling in the vertebrate limb. Nature Cell Biology 5: 513-519.
  • Groppe, J., Greenwald, J., Wiater, E.,Rodriguez-Leon, J., Economides, A.N., Kwiatkowski, W., Affolter, M., Vale, W.W., Izpisúa Belmonte JC and Choe, S. (2002) Structural basis of BMPsignalling inhibition by the cystine knot protein Noggin. Nature 420: 636-642.
  • Izpisúa Belmonte JC. (2002) The limb identitygene Tbx5 promotes limb initiation by interacting with Wnt-2band Fgf-10. Development 129: 5161-5170.
  • Ng, J., Kawakami, Y., Büscher, D., Raya,A., Itoh, T., Koth, C., Rodríguez Esteban, C., Rodriguez Leon, J., Garrity, D.M., Fishman, M.C. Hurle, J.M. and Izpisúa Belmonte JC. (Ed.). (2002) Limb Development, Special Issue. Intl.Jnl. of Dev. Biol., Volume 46, Issue No. 7.
  • Diaz Trelles, R., Rodriguez Leon, J., Kawakami, Y., Simoes, S. and Izpisúa Belmonte JC. (2002) Expression of thechick vascular endothelial growth factor D gene during limbdevelopment. Mechanisms of Development 116: 239-242.
  • Capdevila, J. and Izpisúa Belmonte JC. (2001) Patterning mechanisms controlling vertebrate limb development. Ann. Rev. Cell Dev. Biol. 17: 87-132.
  • Rodriguez-Esteban, C., Raya, A.,Capdevila, J. and Izpisúa Belmonte JC. (2001) ¿Cómo distingue el cuerpo la izquierda de la derecha? Investigacion y Ciencia 300: 62-69.
  • Mukhopadhyay, M., Shtrom, S.,Rodriguez-Esteban, C., Chen, L., Tsukui, T., Gomer, L., Dorward, D.W.,Glinka, A., Grinberg, A., Huang, S.-P., Niehrs, C., Izpisúa Belmonte JC and Westphal, H. (2001) Dickkopf1 is required for embryonic headinduction and limb morphogenesis in the mouse. Developmental Cell 1: 423-434.
  • Tavares, A.T., Izpisúa Belmonte JC and Rodriguez-Leon, J. (2001) Developmental expression of chick Twistand its regulation during limb patterning. Intl. Jnl. of Dev.Biol. 45: 707-713.
  • Rodriguez-Esteban, C., Capdevila, J., Kawakami, Y. and Izpisúa Belmonte JC. (2001) Wnt signaling and PKAcontrol Nodal expression and left-right determination in the chickembryo. Development 128: 3189-3195.
  • Sharma, K. and Izpisúa Belmonte JC. (2001) Development of the limb neuromuscular system. Curr. Opin. CellBiol. 13: 204-210.
  • Kawakami, Y., Capdevila, J., Büscher,D., Itoh, T., Rodriguez-Esteban, C., and Izpisúa Belmonte JC. (2001) Wnt signals control FGF-dependent limb initiation and AER induction in thechick embryo. Cell 104: 891-900.
  • Capdevila, J. and Izpisúa Belmonte JC. (2000) Perspectives on the evolutionary origin of tetrapod limbs. Jnl.of Exp. Zool 288: 287-303.
  • Ruiz-Lozano, P., Ryan, A.K. and Izpisúa Belmonte JC. (2000) Left-right axis determination. Trends inCardiovascular Med 10: 258-262.
  • Liang, J.O., Etheridge,A., Hantsoo, L., Rubinstein, A.L., Nowak, S.J., Izpisúa Belmonte JC, and Halpern, M.E. (2000) Asymmetric Nodal signaling in the zebrafish diencephalons positionsthe pineal organ. Development 127: 5101-5112.
  • Ryan, A.K. and Izpisúa Belmonte JC. (2000) Establishing a left-right axis in the embryo. IUBMB Life 50: 1-11.
  • Tavares, A.T., Tsukui, T., and Izpisúa Belmonte JC. (2000) Evidence that members of the Cut/Cux/CDP familymay be involved in AER positioning and polarizing activity during chicklimb development. Development 127: 5133-5144.
  • Yokoyama, H., Yonei-Tamura, S., Endo,T., Izpisúa Belmonte JC, Tamura, K. and Ide, H. (2000) Mesenchymewith Fgf-10 expression is responsible for regenerative capacity in Xenopuslimb buds. Developmental Biol 219: 18-29.
  • Capdevila, J., Vogan, K.J., Tabin, C.J.and Izpisúa Belmonte JC. (2000) Mechanisms of left-right determinationin vertebrates. Cell 101: 9-21.
  • Capdevila, J. and Izpisúa Belmonte JC. (2000) Knowing left from right: the molecular basis of lateralitydefects. Mol. Med. Today 6: 112-118.
  • Tamura, K., Yonei-Tamura, S. and Izpisúa Belmonte JC. (1999) Differential expression of Tbx4 and Tbx5in Zebrafish fin buds. Mech. Dev 87: 181-184.
  • Capdevila, J., Tsukui, T.,Rodriguez-Esteban, C., Zappavigna, V. and Izpisúa Belmonte JC. (1999) Control of vertebrate limb outgrowth by the proximal factor Meis2 anddistal antagonism of BMPs by Gremlin. Mol. Cell 4: 839-849.
  • Tamura, K., Yonei-Tamura, S. and Izpisúa Belmonte JC. (1999) Molecular basis of left-right asymmetry. Dev.Growth Differ 41: 645-656.
  • Tsukui, T., Capdevila, J., Tamura, K.,Ruiz-Lozano, P., Rodriguez-Esteban, C., Yonei-Tamura, S., Magallon, J.,Chandraratna, R.A.S., Chien, K., Blumberg, B., Evans, R.M. and Izpisúa Belmonte JC. (1999) Multiple left-right asymmetry defects in Shh-/-mutant mice unveil a convergence of the Shh and Retinoic Acid pathwaysin the control of Lefty-1. Proc. Natl. Acad. Sci. USA 96: 11376-11381.
  • Tavares, A., Capdevila, J. and Izpisúa Belmonte JC. (1999) Transcription factors during limb development. Scientific American (Sp. edit.) 4, 30-32.
  • Lin, C.R., Kioussi, C.,O'Connell, S., Briata, P., Szeto, D., Liu, F., Izpisúa Belmonte JC and Rosenfeld, M.G. (1999) Pitx2 regulates lung asymmetry, cardiac positioningand pituitary and tooth morphogenesis. Nature 401: 279-282.
  • Rodriguez-Esteban, C.,Capdevila, J., Economides, A.N., Pascual, J., Ortiz, A. and Izpisúa Belmonte JC. (1999) The novel Cer-like protein Caronte mediates the establishment ofembryonic left-right asymmetry. Nature 401: 243-251.
  • Yamada, G., Nakamura, S., Fukuzaki, K.,Izumi, H., Horai, N., Nagata, R., Minami, T., Tohno, Y., Suzuki, K.,Haraguchi, R., Miyado, K., Toyoda, T., Izpisúa Belmonte JC, Maruyama,I. and Kitajima, I. (1999) Dysregulation of trace element composition inovariectomized cynomolgus monkey bones. Cell. & Mol. Biol 44: 1205-1213.
  • Garcia-Domingo, D., Leonardo, E.,Grandien, A., Martinez, P., Albar, J.P., Izpisúa Belmonte JC and Martinez-A., C. (1999) DIO-1 is a gene involved in onset ofapoptosis in vitro, whose misexpression disrupts limb development. Proc.Natl. Acad. Sci. USA 96: 7992-7997.
  • Bach, I.,Rodriguez-Esteban, C., Carriere, C., Bhushan, A., Krones, A., Rose, D.W.,Glass, C.K., Andersen, B., Izpisúa Belmonte JC and Rosenfeld, M.G. (1999) RLIM inhibits functional activity of LIM homeodomain transcription factors viarecruitment of the histone deacetylase complex. Nature Genet 22: 394-399.
  • Huang, R., Zhi, Q., Izpisúa Belmonte JC, Christ, B. and Ketan, P. (1999) Origin and development of theavian tongue muscles. Anat. Embryol 200: 137-152.
  • Capdevila, J. and Izpisúa Belmonte JC. (1999) Extracellular modulation of the Hedgehog,Wnt and TGF-b signalling pathways during embryonicdevelopment. Curr. Opin. Genet. Dev 9: 427-433.
  • Merino, R., Macias, D.,Gañan, Y., Rodriguez-Leon, J., Economides, A.N., Rodriguez-Esteban, C., Izpisúa Belmonte JC and Hurle, J.M. (1999) Control of digit formation by activinsignalling. Development 126: 2161-2170.
  • Izpisúa Belmonte JC. (1999) How thebody tells left from right. Scientific American 280: 46-51.
  • Li, Q., Lu, Q., Hwang, J.Y., Büscher,D., Lee, K.-F., Izpisúa Belmonte JC and Verma, I.M. (1999) IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev 13: 1322-1328.
  • Rodriguez-Esteban, C., Tsukui, T.,Yonei, S., Magallon, J., Tamura, K. and Izpisúa Belmonte JC. (1999) The T-Box genes Tbx4 and Tbx5 regulate limb outgrowth andidentity. Nature 398: 814-818.
  • Büscher, D. and Izpisúa Belmonte JC. (1999) Muscle development during vertebrate limb outgrowth. Cell & Tissue Res 296: 131-139.
  • Rincon-Limas, D.E., Lu, C.-H., Canal, I., Calleja, M., Rodriguez Esteban, C., Izpisúa Belmonte JC and Botas, J. (1999) Conservation of the expression and function of apterous orthologsin Drosophila and mammals. Proc. Natl. Acad. Sci. USA 96: 2165-2170.
  • Yonei-Tamura, S., Tamura, K., Tsukui, T. and Izpisúa Belmonte JC. (1999) Spatially and temporally-restrictedexpression of two T-box genes during zebrafish embryogenesis. Mech. Dev 80: 219-221.
  • Szeto, D.P., Rodriguez-Esteban, C., Ryan, A.K., O'Connell, S.M., Liu, F., Kioussi, C., Gleiberman, A.S., Izpisúa Belmonte JC and Rosenfeld, M.G. (1999) Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesisand pituitary development. Genes Dev 13: 484-494.
  • Torok, M.A., Gardiner, D.M., Izpisúa Belmonte JC and Bryant, S.V. (1999) Sonic Hedgehog (shh) expressionin developing and regenerating Axolotl limbs. J. of Exp. Zool 284: 197-206.
  • Ng, J.K., Tamura, K., Büscher, D. and Izpisúa Belmonte JC. (1999) Outgrowth and patterning of the vertebratelimb. Molecular and cellular basis of pattern formation during vertebrate limb development. Current Topics in Dev. Biol 41: 37-66.
  • Takahashi, M., Tamura, K., Büscher, D.,Masuya, H., Yonei-Tamura, S., Matsumoto, K., Naitoh-Matsuo, M., Takeuchi,J., Ogura, K., Shiroishi, T., Ogura, T. and Izpisúa Belmonte JC. (1998) The role of Alx-4 in the establishment of anteroposteriorpolarity during vertebrate limb outgrowth. Development 125: 4417-4425.
  • Rodriguez-Esteban, C., Schwabe, J.W.R.,De La Peña, J., Rincon-Limas, D.E., Magallon, J., Botas, J. and Izpisúa Belmonte JC. (1998) Lhx2, a vertebrate homologue of apterous,regulates vertebrate limb outgrowth. Development 125: 3925-3934.
  • Ryan, A., Blumberg, B.,Rodriguez-Esteban, C., Yonei-Tamura, S., Tamura, K., Tsukui, T., De LaPeña, J., Sabbagh, W., Greenwald, J., Choe, S., Norris, D.P., Robertson,E.J., Evans, R.M., Rosenfeld, M.G. and Izpisúa Belmonte JC. (1998) Pitx2determines left-right asymmetry of internal organs in vertebrates. Nature 394: 545-551.
  • Schwabe, J.W.R., Rodriguez-Esteban, C.and Izpisúa Belmonte JC. (1998) Limbs are moving...where are they going? Trends in Genetics 14: 229-235.
  • Isaac, A., Rodriguez-Esteban, C., Ryan,A., Altabef, M., Tsukui, T., Patel, K., Tickle, C. and Izpisúa Belmonte JC. (1998) Tbx genes and limb identity in chick embryo development. Development 125: 1867-1875.
  • Kengaku, M., Capdevila, J., Rodriguez-Esteban, C., De La Peña, J., Johnson, R.L., Izpisúa Belmonte JC and Tabin, C.J. (1998) Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science 280: 1274-1277.
  • Capdevila, J., Rodriguez-Esteban, C. and Izpisúa Belmonte JC. (1998) Molecular architecture of the vertebrate limb. Scientific American 12: 23-37 (Sp. edit.).
  • Kanegae, Y., Tavares, A.T., Izpisúa Belmonte JC and Verma, I.M. (1998) Role of Rel/NF-KB transcription factors during the outgrowth of the vertebrate limb. Nature 392: 611-614.
  • Heanue, T.A., Johnson, R.L., Izpisúa Belmonte JC, Stern, C.D., DeRobertis, E.M. and Tabin, C.J. (1997) Goosecoidmisexpression alters the morphology and Hox gene expression of the developing chick limb bud. Mech. Dev 69: 31-37.
  • Schwabe, J.W.R.,Rodriguez-Esteban, C., De La Peña, J., Tavares, A., Ng, J., Banayo, E.M., Foys,B., Eshelman, B., Magallon, J., Tam, R. and Izpisúa Belmonte JC. (1997) Outgrowth and patterning of the vertebrate limb. Cold Spring Harbor Symposia on Biology, Vol. LXII: 431-435.
  • Pfeffer, P., De Robertis, E. and Izpisúa Belmonte JC. (1997) Crescent, a nove

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