The primary objective of the human ESC registry is to provide information about all human ESC lines derived in Europe and also the non-European lines, which are available to the scientific community at large. The growing use of hESC by the scientific community demands not a list of cells but a comprehensive registry and this demand will be served. All available characterizing information will be monitored and collected about each registered hES cell line in addition to origin, derivation methodology, as well as the different parameters used for their characterisation. Each cell line will be annotated with regularly updated information on its features and applications. Contact and availability information will also be accessible for each cell line. Finally, the registry will provide an international platform that is expected to contribute actively to the establishment of standardized evaluation parameters for human ESC lines. This registry will operate through an internet website with open access.
The registry is coordinated by groups at the Center of Regenerative Medicine in Barcelona and at the Berlin Center for Regenerative Therapies at the Charité. National representatives from each European country, in which human ESC lines can be legally derived, form the Steering Committee of the registry. The Steering Committee forms the bridge to the national researchers and provides updated information about scientific and legal developments in their country and the cell lines that are available. The Scientific Advisory Board (SAB), constituted of leading European and non-European scientists in the field of hESC research will advise and assure the scientific and technical quality of the registry. An independent Ethics Advisory Board will guide the registry on ethical issues.
The European human ESC registry will promote the validation and efficient use of the knowledge related to these cells for research and application by providing overview and comparability to the wider scientific community. This registry aims to become the first European registry of hESC lines in terms of size, quality and accuracy of the information delivered and its usefulness for the scientific community. The registry will contribute to the responsible limitation of the number of embryos needed for derivation of new cell lines by promoting access to existing hESC lines, exchange of information about these cells and transparency towards the European legislative landscape.