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Olalla Iglesias García

Olalla Iglesias García

oiglesias@cmrb.eu


Dr. Olalla Iglesias obtained her bachelor´s degree in Pharmacy at University of Salamanca in 2007. She continued her studies with a Master´s degree in Molecular & Cellular Biology at University of Navarra.

Afterwards, between 2008 and 2013, she did her International PhD at the laboratory of Cellular Therapy of the Dr. Felipe Prosper at the Center for Applied Medical Research (CIMA) of the University of Navarra. Her research was focused on the study of the regenerative potential of induced pluripotent stem (iPS) cells in a model of acute myocardial infarction in mice.

In 2011, during her PhD, she visited the laboratory of professor Juerguen Hescheler at the Institute of Neurophisiolgy of the University of Cologne (Germany), where she analyzed the phenotype and level of maturation of iPS-derived cardiomyocytes.

Upon completion of her PhD, she continued her scientific work at the CIMA, from 2013 to 2015, developing different strategies to promote the engraftment and survival of iPS-derived cardiomyocytes.

In March 2015, she joined as a postdoctoral researcher at the Center of Regenerative Medicine in Barcelona (CMRB) focusing on the differentiation of hESC/hiPS cells toward functional cardiomyocytes for pre-clinical testing in large animal models.



Selected Publications

  • Valls-Margarit M, Iglesias-García O, Di Guglielmo C, Sarlabous L, Tadevosyan K, Paoli R, Comelles J, Blanco D, Jimenez-Delgado S, Castillo-Fernández O, Samitier J, Jané R, Martínez E, Raya A. (2019) Engineered Macroscale Cardiac Constructs Elicit Human Myocardial Tissue-like Functionality. Stem Cell Rep 13(1):207-220. Epub 2019, Jun 7
  • Saludas L, Garbayo E, Mazo M, Pelacho B, Abizanda G, Iglesias Garcia O, Raya A, Prosper F, Blanco-Prieto MJ. (2019) Long-term engraftment of human cardiomyocytes combined with biodegradable microparticles induces heart repair. J Pharmacol Exp Ther pii: jpet.118.256065. Epub 2019, Feb 6.
  • Coppiello G, Abizanda G, Aguado N, Iglesias E, Iglesias-Garcia O, Lo Nigro A, Prosper F, Aranguren XL. (2017) Generation of a Sprague-Dawley-GFP rat iPS cell line. Stem Cell Res. 21:47-50. Epub 2017, Mar 31.
  • Coppiello G, Abizanda G, Aguado N, Iglesias E, Iglesias-Garcia O, Lo Nigro A, Prosper F, Aranguren XL. (2017) Isolation and characterization of Sprague-Dawley and Wistar Kyoto GFP rat embryonic stem cells. . Stem Cell Res. 21:40-43. Epub 2017, Mar 29.
  • Gálvez-Montón C, Soler-Botija C, Iborra-Egea O, Diaz-Guemes I, Martí M, Iglesias-Garcia O, Prat-Vidal C, Crisóstomo V, Llucià-Valldeperas A, Perea-Gil I, Roura S, Sanchez Margallo FM, Raya Á, Bayés-Genís A. (2017) Preclinical safety evaluation of allogeneic iPS cell-based therapy in a swine model of myocardial infarction. . Tissue Eng Part C Methods. 23(11):736-744 Epub 2017, Aug 18.
  • Linares J, Arellano-Viera E, Iglesias-García O, Ferreira C, Iglesias E, Abizanda G, Prósper F, Carvajal-Vergara X. (2016) Generation of iPSC from cardiac and tail-tip fibroblasts derived from a second heart field reporter mouse. Stem Cells Res 16(3):617-21. Epub 2016 Mar 19.
  • Macri-Pellizzeri L, Pelacho B, Sancho A, Iglesias-Garcia O, Simon-Yarza AB, Soriano-Navarro M, Gonzalez-Granero S, García Verdugo JM, Dejuanpardo E, Prosper F. (2015) Substrate stiffness and composition specifically direct differentiation of  induced pluripotent stem cells. Tissue Eng Part A Epub 2015 Mar 18.
  • Iglesias-García O, Baumgartner S, Macrí-Pellizzeri L, Rodriguez-Madoz JR, Abizanda G, Guruceaga E, Albiasu E, Corbacho D, Benavides-Vallve C, Soriano-Navarro M, González-Granero S, Gavira JJ, Krausgrill B, Rodriguez-Mañero M, García-Verdugo JM, Ortiz-de-Solorzano C, Halbach M, Hescheler J, Pelacho B, Prósper F. (2015) Neuregulin-1β induces mature ventricular cardiac differentiation from induced pluripotent stem cells contributing to cardiac tissue repair. Stem Cells Dev 15;24(4):484-96. Epub 2014 Nov 25.
  • Andreu I, Luque T, Sancho A, Pelacho B, Iglesias-García O, Melo E, Farré R, Prósper F, Elizalde MR, Navajas D. (2014) Heterogeneous micromechanical properties of the extracellular matrix in healthy and infarcted hearts. Acta Biomater 10(7):3235-42. Epub 2014 Apr 6.
  • Iglesias-García O, Pelacho B, Prósper F. (2013) Induced pluripotent stem cells as a new strategy for cardiac regeneration and disease modeling. J Mol Cell Cardiol 62:43-50. Epub 2013 Apr 30.
  • Benavides-Vallve C, Corbacho D, Iglesias-Garcia O, Pelacho B, Albiasu E, Castaño S, Muñoz-Barrutia A, Prosper F, Ortiz-de-Solorzano C. (2012) New strategies for echocardiographic evaluation of left ventricular function in a mouse model of long-term myocardial infarction. PLoS One 7(7):e41691. Epub 2012 Jul 27.



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