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Maria Carolina Florian

Maria Carolina Florian

Group leader

cflorian@cmrb.eu


Dr. M. Carolina Florian holds a PhD from the University of Milano (Italy). She pursued postdoctoral training at the Institute of Molecular Medicine in Ulm University (Germany) from 2009 to 2015. In 2016, she was awarded an Emmy Noether Grant from the German Research Foundation (DFG) dedicated to outstanding early-career researchers. This grant supported the establishment of her independent research team on Epigenetics of Stem Cell Aging. In 2018, she was appointed as group leader at CMRB (Spain).


Her research in the past 5 years strongly challenged the concept that aging is an irreversible process and showed that it is possible to pharmacologically target the aged-dependent alteration of stem cell epigenetic polarity and functionally rejuvenate aged HSCs in vivo. Somatic stem cells are central for tissue homeostasis and regeneration. Their age-dependent functional decline constitutes a hallmark of tissue attrition upon aging, eventually limiting health-span and lifespan. Dr. Florian’s work is committed to further grow the understanding of alterations affecting aged somatic stem cells and she is investigating changes of the epigenetic architecture that drive stem cell aging, to improve tissue attrition with age or even to prevent aging-associated diseases.



Selected Publications

  • Klose M, Florian MC, Gerbaulet A, Geiger H, Glauche I. (2019) Hematopoietic Stem Cell Dynamics are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach. Stem Cells 37(7):948-957 Epub 2019, Mar 21.
  • Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, Vollmer A, Markaki Y, Leonhardt H, Buske C, Lipka DB, Plass C, Zheng Y, Mulaw MA, Geiger H, Florian MC. (2018) LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome Biol 19(1):189.
  • Grigoryan, A., Guidi, N., Senger, K., Liehr, T., Soller, K., Marka, G., Vollmer, A., Markaki, Y., Leonhardt, H., Buske, C., Lipka, D. B., Plass, C., Zheng, Y., Mulaw, M. A., Geiger, H., and Florian, M. C. (2018) LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome Biol 19(1): 189.
  • Liu, W., Du, W., Shang, X., Wang, L., Evelyn, C., Florian, M. C., M, A. R., Rayes, A., Zhao, X., Setchell, K., Meller, J., Guo, F., Nassar, N., Geiger, H., Pang, Q., and Zheng, Y. (2018) Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Leukemia Epub 2018, Sep 25.
  • Florian, M. C., Klose, M., Sacma, M., Jablanovic, J., Knudson, L., Nattamai, K. J., Marka, G., Vollmer, A., Soller, K., Sakk, V., Cabezas-Wallscheid, N., Zheng, Y., Mulaw, M. A., Glauche, I., and Geiger, H. (2018) Aging alters the epigenetic asymmetry of HSC division. PLoS Biol 16(9): e2003389.
  • Senger, K., Marka, G., Soller, K., Sakk, V., Florian, M. C., and Geiger, H. (2017) Septin 6 regulates engraftment and lymphoid differentiation potential of murine long-term hematopoietic stem cells. Exp Hematol 55: 45-55.
  • Schreck, C., Istvanffy, R., Ziegenhain, C., Sippenauer, T., Ruf, F., Henkel, L., Gartner, F., Vieth, B., Florian, M. C., Mende, N., Taubenberger, A., Prendergast, A., Wagner, A., Pagel, C., Grziwok, S., Gotze, K. S., Guck, J., Dean, D. C., Massberg, S., Essers, M., Waskow, C., Geiger, H., Schiemann, M., Peschel, C., Enard, W., and Oostendorp, R. A. (2017) Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells. J Exp Med 214: 165-181.
  • Guidi, N., Sacma, M., Standker, L., Soller, K., Marka, G., Eiwen, K., Weiss, J. M., Kirchhoff, F., Weil, T., Cancelas, J. A., Florian, M. C., and Geiger, H. (2017) Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. EMBO J 36(10): 1463.
  • Florian, M. C., Klenk, J., Marka, G., Soller, K., Kiryakos, H., Peter, R., Herbolsheimer, F., Rothenbacher, D., Denkinger, M., and Geiger, H. (2017) Expression and activity of the small RhoGTPase Cdc42 in blood cells of older adults are associated with age and cardiovascular disease. J Gerontol A Biol Sci Med Sci 72(9): 1196-1200.
  • Cabezas-Wallscheid, N., Buettner, F., Sommerkamp, P., Klimmeck, D., Ladel, L., Thalheimer, F. B., Pastor-Flores, D., Roma, L. P., Renders, S., Zeisberger, P., Przybylla, A., Schonberger, K., Scognamiglio, R., Altamura, S., Florian, C. M., Fawaz, M., Vonficht, D., Tesio, M., Collier, P., Pavlinic, D., Geiger, H., Schroeder, T., Benes, V., Dick, T. P., Rieger, M. A., Stegle, O., and Trumpp, A. (2017) Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy. Cell 169: 807-823 e819.
  • Moehrle, B. M., Nattamai, K., Brown, A., Florian, M. C., Ryan, M., Vogel, M., Bliederhaeuser, C., Soller, K., Prows, D. R., Abdollahi, A., Schleimer, D., Walter, D., Milsom, M. D., Stambrook, P., Porteus, M., and Geiger, H. (2015) Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs. Cell Rep 13(11): 2412-2424.
  • Denkinger, M. D., Leins, H., Schirmbeck, R., Florian, M. C., and Geiger, H. (2015) HSC Aging and Senescent Immune Remodeling. Trends Immunol 36(12): 815-824.
  • Zhou, X., Florian, M. C., Arumugam, P., Chen, X., Cancelas, J. A., Lang, R., Malik, P., Geiger, H., and Zheng, Y. (2013) RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors. J Exp Med 210(11): 2371-2385.
  • Geiger, H., de Haan, G., and Florian, M. C. (2013) The ageing haematopoietic stem cell compartment. Nat Rev Immunol 13(5): 376-389.
  • Florian, M. C., Nattamai, K. J., Dorr, K., Marka, G., Uberle, B., Vas, V., Eckl, C., Andra, I., Schiemann, M., Oostendorp, R. A., Scharffetter-Kochanek, K., Kestler, H. A., Zheng, Y., and Geiger, H. (2013) A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature 503(7476) 392-396.
  • Florian, M. C., Dorr, K., Niebel, A., Daria, D., Schrezenmeier, H., Rojewski, M., Filippi, M. D., Hasenberg, A., Gunzer, M., Scharffetter-Kochanek, K., Zheng, Y., and Geiger, H. (2012) Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 10(5): 520-530.
  • Sengupta, A., Duran, A., Ishikawa, E., Florian, M. C., Dunn, S., Fickera, A., Leitgese, M., Geiger, H., Diaz-Mecob, M., Moscatb, J., and Cancelas, J. A. (2011) aPKCζ and aPKCλ are dispensable for mammalian hematopoietic stem cell activity and blood formation. Proc Natl Acad Sci USA 108(24): 9957-9962.
  • Florian, M. C., and Geiger, H. (2010) Concise review: polarity in stem cells, disease, and aging. Stem Cells 28(9): 1623-1629.
  • Evangelisti, C., Florian, M. C., Massimi, I., Dominici, C., Giannini, G., Galardi, S., Bue, M. C., Massalini, S., McDowell, H. P., Messi, E., Gulino, A., Farace, M. G., and Ciafre, S. A. (2009) MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness. FASEB J 23: 4276-4287.
  • Messi, E., Florian, M. C., Caccia, C., Zanisi, M., and Maggi, R. (2008) Retinoic acid reduces human neuroblastoma cell migration and invasiveness: effects on DCX, LIS1, neurofilaments-68 and vimentin expression. BMC Cancer 8, 30.



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